CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes

An oncogenic role for CHD4, a NuRD component, is defined for initiating and supporting tumor suppressor gene (TSG) silencing in human colorectal cancer. CHD4 recruits repressive chromatin proteins to sites of DNA damage repair, including DNA methyltransferases where it imposes de novo DNA methylatio...

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Bibliografiset tiedot
Julkaisussa:Cancer Cell
Päätekijät: Xia, Limin, Huang, Wenjie, Bellani, Marina, Seidman, Michael M., Wu, Kaichun, Fan, Daiming, Nie, Yongzhan, Cai, Yi, Zhang, Yang W., Yu, Li-Rong, Li, Huili, Zahnow, Cynthia A., Xie, Wenbing, Yen, Ray-Whay Chiu, Rassool, Feyruz V., Baylin, Stephen B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587180/
https://ncbi.nlm.nih.gov/pubmed/28486105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.04.005
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