Defining UHRF1 Domains That Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties

UHRF1 facilitates the establishment and maintenance of DNA methylation patterns in mammalian cells. The establishment domains are defined, including E3 ligase function, but the maintenance domains are poorly characterized. Here, we demonstrate UHRF1 histone- and hemi-methylated DNA binding functions...

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Bibliografske podrobnosti
izdano v:Cancer Cell
Main Authors: Kong, Xiangqian, Chen, Jie, Xie, Wenbing, Brown, Stephen M., Cai, Yi, Wu, Kaichun, Fan, Daiming, Nie, Yongzhan, Yegnasubramanian, Srinivasan, Tiedemann, Rochelle L., Tao, Yong, Yen, Ray-Whay Chiu, Topper, Michael J., Zahnow, Cynthia A., Easwaran, Hariharan, Rothbart, Scott B., Xia, Limin, Baylin, Stephen B.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521721/
https://ncbi.nlm.nih.gov/pubmed/30956060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.03.003
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