Defining UHRF1 Domains That Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties

UHRF1 facilitates the establishment and maintenance of DNA methylation patterns in mammalian cells. The establishment domains are defined, including E3 ligase function, but the maintenance domains are poorly characterized. Here, we demonstrate UHRF1 histone- and hemi-methylated DNA binding functions...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cancer Cell
मुख्य लेखकों: Kong, Xiangqian, Chen, Jie, Xie, Wenbing, Brown, Stephen M., Cai, Yi, Wu, Kaichun, Fan, Daiming, Nie, Yongzhan, Yegnasubramanian, Srinivasan, Tiedemann, Rochelle L., Tao, Yong, Yen, Ray-Whay Chiu, Topper, Michael J., Zahnow, Cynthia A., Easwaran, Hariharan, Rothbart, Scott B., Xia, Limin, Baylin, Stephen B.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521721/
https://ncbi.nlm.nih.gov/pubmed/30956060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.03.003
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