DNA methylation patterns separate senescence from transformation potential and indicate cancer risk

Overall shared DNA methylation patterns between senescence (Sen) and cancers have led to the model that tumor promoting epigenetic patterns arise through senescence. We show that transformation-associated methylation changes arise stochastically and independently of programmatic changes during senes...

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I publikationen:Cancer Cell
Huvudupphovsmän: Xie, Wenbing, Kagiampakis, Ioannis, Pan, Lixia, Zhang, Yang W., Murphy, Lauren, Tao, Yong, Kong, Xiangqian, Xia, Limin, Carvalho, Filipe LF, Sen, Subhojit, Yen, Ray-Whay Chiu, Zahnow, Cynthia A., Ahuja, Nita, Baylin, Stephen B., Easwaran, Hariharan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813821/
https://ncbi.nlm.nih.gov/pubmed/29438699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.01.008
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