High glucose‐mediated PICALM and mTORC1 modulate processing of amyloid precursor protein via endosomal abnormalities

BACKGROUND AND PURPOSE: Although diabetes mellitus (DM) is an important risk factor for Alzheimer's disease (AD), the detailed mechanism(s) by which DM regulates amyloid β (Aβ) processing is still unclear. The longer residence time of amyloid precursor protein (APP) in endosomes is critical for...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Chae, Chang Woo, Lee, Hyun Jik, Choi, Gee Euhn, Jung, Young Hyun, Kim, Jun Sung, Lim, Jae Ryong, Kim, Seo Yihl, Hwang, In Koo, Seong, Je Kyung, Han, Ho Jae
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393198/
https://ncbi.nlm.nih.gov/pubmed/32436237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15131
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