Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death

Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by cognitive impairment and memory loss. Amyloid β1-42 (Aβ) and hyper-phosphorylation of microtubule-associated protein tau have been considered as major histological features in AD. However, the mechanism of how Aβ induces the...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Lee, Ki Hoon, Lee, Sei-Jung, Lee, Hyun Jik, Choi, Gee Euhn, Jung, Young Hyun, Kim, Dah Ihm, Gabr, Amr Ahmed, Ryu, Jung Min, Han, Ho Jae
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522873/
https://ncbi.nlm.nih.gov/pubmed/28790888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00229
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