High glucose‐mediated PICALM and mTORC1 modulate processing of amyloid precursor protein via endosomal abnormalities

BACKGROUND AND PURPOSE: Although diabetes mellitus (DM) is an important risk factor for Alzheimer's disease (AD), the detailed mechanism(s) by which DM regulates amyloid β (Aβ) processing is still unclear. The longer residence time of amyloid precursor protein (APP) in endosomes is critical for...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Chae, Chang Woo, Lee, Hyun Jik, Choi, Gee Euhn, Jung, Young Hyun, Kim, Jun Sung, Lim, Jae Ryong, Kim, Seo Yihl, Hwang, In Koo, Seong, Je Kyung, Han, Ho Jae
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2020
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393198/
https://ncbi.nlm.nih.gov/pubmed/32436237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15131
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