An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

Since nuclear envelope breakdown occurs during mitosis in metazoan cells, it has been proposed that macroautophagy must be inhibited to maintain genome integrity. However, repression of macroautophagy during mitosis remains controversial and mechanistic detail limited to the suggestion that CDK1 pho...

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Pubblicato in:Mol Cell
Autori principali: Odle, Richard I., Walker, Simon A., Oxley, David, Kidger, Andrew M., Balmanno, Kathryn, Gilley, Rebecca, Okkenhaug, Hanneke, Florey, Oliver, Ktistakis, Nicholas T., Cook, Simon J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964153/
https://ncbi.nlm.nih.gov/pubmed/31733992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.016
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