An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

Since nuclear envelope breakdown occurs during mitosis in metazoan cells, it has been proposed that macroautophagy must be inhibited to maintain genome integrity. However, repression of macroautophagy during mitosis remains controversial and mechanistic detail limited to the suggestion that CDK1 pho...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Odle, Richard I., Walker, Simon A., Oxley, David, Kidger, Andrew M., Balmanno, Kathryn, Gilley, Rebecca, Okkenhaug, Hanneke, Florey, Oliver, Ktistakis, Nicholas T., Cook, Simon J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964153/
https://ncbi.nlm.nih.gov/pubmed/31733992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.016
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