Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor

The current COVID-19 pandemic is caused by the SARS-CoV-2 betacoronavirus, which utilizes its highly glycosylated trimeric Spike protein to bind to the cell surface receptor ACE2 glycoprotein and facilitate host cell entry. We utilized glycomics-informed glycoproteomics to characterize site-specific...

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發表在:bioRxiv
Main Authors: Zhao, Peng, Praissman, Jeremy L., Grant, Oliver C., Cai, Yongfei, Xiao, Tianshu, Rosenbalm, Katelyn E., Aoki, Kazuhiro, Kellman, Benjamin P., Bridger, Robert, Barouch, Dan H., Brindley, Melinda A., Lewis, Nathan E., Tiemeyer, Michael, Chen, Bing, Woods, Robert J., Wells, Lance
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386495/
https://ncbi.nlm.nih.gov/pubmed/32743578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.06.25.172403
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