Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor

The SARS-CoV-2 betacoronavirus uses its highly glycosylated trimeric Spike protein to bind to the cell surface receptor angiotensin converting enzyme 2 (ACE2) glycoprotein and facilitate host cell entry. We utilized glycomics-informed glycoproteomics to characterize site-specific microheterogeneity...

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Bibliographic Details
Published in:Cell Host Microbe
Main Authors: Zhao, Peng, Praissman, Jeremy L., Grant, Oliver C., Cai, Yongfei, Xiao, Tianshu, Rosenbalm, Katelyn E., Aoki, Kazuhiro, Kellman, Benjamin P., Bridger, Robert, Barouch, Dan H., Brindley, Melinda A., Lewis, Nathan E., Tiemeyer, Michael, Chen, Bing, Woods, Robert J., Wells, Lance
Format: Artigo
Language:Inglês
Published: Elsevier Inc. 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443692/
https://ncbi.nlm.nih.gov/pubmed/32841605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.08.004
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