Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor

The current COVID-19 pandemic is caused by the SARS-CoV-2 betacoronavirus, which utilizes its highly glycosylated trimeric Spike protein to bind to the cell surface receptor ACE2 glycoprotein and facilitate host cell entry. We utilized glycomics-informed glycoproteomics to characterize site-specific...

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Publicado en:bioRxiv
Main Authors: Zhao, Peng, Praissman, Jeremy L., Grant, Oliver C., Cai, Yongfei, Xiao, Tianshu, Rosenbalm, Katelyn E., Aoki, Kazuhiro, Kellman, Benjamin P., Bridger, Robert, Barouch, Dan H., Brindley, Melinda A., Lewis, Nathan E., Tiemeyer, Michael, Chen, Bing, Woods, Robert J., Wells, Lance
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386495/
https://ncbi.nlm.nih.gov/pubmed/32743578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.06.25.172403
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