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Potent and rapid reversal of the von Willebrand factor inhibitor aptamer BT200
BACKGROUND: BT200, a pegylated form of the aptamer BT100, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis in cynomolgus monkeys. It is being developed for secondary prevention of arterial thrombosis such as stroke or myocardial infarction...
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| Veröffentlicht in: | J Thromb Haemost |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7384040/ https://ncbi.nlm.nih.gov/pubmed/32275107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14822 |
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