Potent and rapid reversal of the von Willebrand factor inhibitor aptamer BT200

BACKGROUND: BT200, a pegylated form of the aptamer BT100, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis in cynomolgus monkeys. It is being developed for secondary prevention of arterial thrombosis such as stroke or myocardial infarction...

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Bibliografske podrobnosti
izdano v:J Thromb Haemost
Main Authors: Zhu, Shuhao, Gilbert, James C., Liang, Zicai, Kang, Daiwu, Li, Ming, Tarantino, Paul M., Jilma, Bernd
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
THROMBOSIS
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384040/
https://ncbi.nlm.nih.gov/pubmed/32275107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14822
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