The development and characterization of a long acting anti‐thrombotic von Willebrand factor (VWF) aptamer

BACKGROUND: Thrombus formation involves coagulation proteins and platelets. The latter, referred to as platelet‐mediated thrombogenesis, is predominant in arterial circulation. Platelet thrombogenesis follows vascular injury when extracellular von Willebrand factor (VWF) binds via its A3 domain to e...

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Vydáno v:J Thromb Haemost
Hlavní autoři: Zhu, Shuhao, Gilbert, James C., Hatala, Paul, Harvey, Warren, Liang, Zicai, Gao, Shan, Kang, Daiwu, Jilma, Bernd
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
THROMBOSIS
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317574/
https://ncbi.nlm.nih.gov/pubmed/32011054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14755
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