Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling

Most cancer cells experience oncogene-induced replication stress and, as a result, exhibit high intrinsic activation of the ATR kinase. Although cancer cells often become more dependent on ATR for survival, the precise mechanism by which ATR signaling ensures cancer cell fitness and viability remain...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:NAR Cancer
Main Authors: Dibitetto, Diego, Sims, Jennie R, Ascenção, Carolline F R, Feng, Kevin, Kim, Dongsung, Oberly, Susannah, Freire, Raimundo, Smolka, Marcus B
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
DNA Damage Sensing and Repair
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380482/
https://ncbi.nlm.nih.gov/pubmed/32743550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa006
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker