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Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling
Most cancer cells experience oncogene-induced replication stress and, as a result, exhibit high intrinsic activation of the ATR kinase. Although cancer cells often become more dependent on ATR for survival, the precise mechanism by which ATR signaling ensures cancer cell fitness and viability remain...
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| Publicado no: | NAR Cancer |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7380482/ https://ncbi.nlm.nih.gov/pubmed/32743550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa006 |
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