ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells

The ATR kinase is crucial for genome maintenance, but the mechanisms by which ATR controls the DNA repair machinery are not fully understood. Here, we find that long-term chronic inhibition of ATR signaling severely impairs the ability of cells to utilize homologous recombination (HR)-mediated DNA r...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Kim, Dongsung, Liu, Yi, Oberly, Susannah, Freire, Raimundo, Smolka, Marcus B
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144784/
https://ncbi.nlm.nih.gov/pubmed/30010936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky625
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