Opposing roles for 53BP1 during homologous recombination

Although DNA non-homologous end-joining repairs most DNA double-strand breaks (DSBs) in G2 phase, late repairing DSBs undergo resection and repair by homologous recombination (HR). Based on parallels to the situation in G1 cells, previous work has suggested that DSBs that undergo repair by HR predom...

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Détails bibliographiques
Auteurs principaux: Kakarougkas, Andreas, Ismail, Amani, Klement, Karolin, Goodarzi, Aaron A., Conrad, Sandro, Freire, Raimundo, Shibata, Atsushi, Lobrich, Markus, Jeggo, Penny A.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2013
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834810/
https://ncbi.nlm.nih.gov/pubmed/23969417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt729
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