ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

Homologous recombination (HR) and non-homologous end joining (NHEJ) represent distinct pathways for repairing DNA double-strand breaks (DSBs). Previous work implicated Artemis and ATM in an NHEJ-dependent process, which repairs a defined subset of radiation-induced DSBs in G1-phase. Here, we show th...

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Main Authors: Beucher, Andrea, Birraux, Julie, Tchouandong, Leopoldine, Barton, Olivia, Shibata, Atsushi, Conrad, Sandro, Goodarzi, Aaron A, Krempler, Andrea, Jeggo, Penny A, Löbrich, Markus
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752027/
https://ncbi.nlm.nih.gov/pubmed/19779458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.276
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