DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination

Canonical non-homologous end joining (c-NHEJ) repairs DNA double-strand breaks (DSBs) in G1 cells with biphasic kinetics. We show that DSBs repaired with slow kinetics, including those localizing to heterochromatic regions or harboring additional lesions at the DSB site, undergo resection prior to r...

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Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell
Egile Nagusiak: Biehs, Ronja, Steinlage, Monika, Barton, Olivia, Juhász, Szilvia, Künzel, Julia, Spies, Julian, Shibata, Atsushi, Jeggo, Penny A., Löbrich, Markus
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cell Press 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316416/
https://ncbi.nlm.nih.gov/pubmed/28132842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.12.016
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