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DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination

Canonical non-homologous end joining (c-NHEJ) repairs DNA double-strand breaks (DSBs) in G1 cells with biphasic kinetics. We show that DSBs repaired with slow kinetics, including those localizing to heterochromatic regions or harboring additional lesions at the DSB site, undergo resection prior to r...

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書目詳細資料
發表在:Mol Cell
Main Authors: Biehs, Ronja, Steinlage, Monika, Barton, Olivia, Juhász, Szilvia, Künzel, Julia, Spies, Julian, Shibata, Atsushi, Jeggo, Penny A., Löbrich, Markus
格式: Artigo
語言:Inglês
出版: Cell Press 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316416/
https://ncbi.nlm.nih.gov/pubmed/28132842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.12.016
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