DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination

Canonical non-homologous end joining (c-NHEJ) repairs DNA double-strand breaks (DSBs) in G1 cells with biphasic kinetics. We show that DSBs repaired with slow kinetics, including those localizing to heterochromatic regions or harboring additional lesions at the DSB site, undergo resection prior to r...

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Bibliografiset tiedot
Julkaisussa:Mol Cell
Päätekijät: Biehs, Ronja, Steinlage, Monika, Barton, Olivia, Juhász, Szilvia, Künzel, Julia, Spies, Julian, Shibata, Atsushi, Jeggo, Penny A., Löbrich, Markus
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cell Press 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316416/
https://ncbi.nlm.nih.gov/pubmed/28132842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.12.016
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