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A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis

DNA double-strand breaks (DSBs) are a hazardous form of damage that can potentially cause cell death or genomic rearrangements. In mammalian G1- and G2-phase cells, DSBs are repaired with two-component kinetics. In both phases, a fast process uses canonical nonhomologous end joining (c-NHEJ) to repa...

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Detalhes bibliográficos
Publicado no:Trends Biochem Sci
Main Authors: Löbrich, Markus, Jeggo, Penny
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Trends Journals 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604544/
https://ncbi.nlm.nih.gov/pubmed/28739276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2017.06.011
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