SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells

Recent studies have shown that homologous recombination (HR) requires chromatin repression as well as relaxation at DNA double strand breaks (DSBs). HP1 and SUV39H1/2 are repressive factors essential for HR. Here, we identify SETDB1 as an additional compacting factor promoting HR. Depletion of HP1,...

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Publicat a:Nucleic Acids Res
Autors principals: Alagoz, Meryem, Katsuki, Yoko, Ogiwara, Hideaki, Ogi, Tomoo, Shibata, Atsushi, Kakarougkas, Andreas, Jeggo, Penny
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652757/
https://ncbi.nlm.nih.gov/pubmed/26206670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv722
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