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Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling
The Mec1/ATR kinase coordinates multiple cellular responses to replication stress. In addition to its canonical role in activating the checkpoint kinase Rad53, Mec1 also plays checkpoint-independent roles in genome maintenance that are not well understood. Here we used a combined genetic–phosphoprot...
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| Vydáno v: | Genes Dev |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6049512/ https://ncbi.nlm.nih.gov/pubmed/29899143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.308148.117 |
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