Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling

The Mec1/ATR kinase coordinates multiple cellular responses to replication stress. In addition to its canonical role in activating the checkpoint kinase Rad53, Mec1 also plays checkpoint-independent roles in genome maintenance that are not well understood. Here we used a combined genetic–phosphoprot...

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Sparad:
Bibliografiska uppgifter
I publikationen:Genes Dev
Huvudupphovsmän: Lanz, Michael Charles, Oberly, Susannah, Sanford, Ethan James, Sharma, Sushma, Chabes, Andrei, Smolka, Marcus Bustamante
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2018
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049512/
https://ncbi.nlm.nih.gov/pubmed/29899143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.308148.117
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