Phosphoproteomics Reveals Distinct Modes of Mec1/ATR Signaling During DNA Replication

The Mec1/Tel1 kinases (human ATR/ATM) play numerous roles in the DNA replication stress response. Despite the multi-functionality of these kinases, studies of their in vivo action have mostly relied on a few well-established substrates. Here we employed a combined genetic-phosphoproteomic approach t...

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Udgivet i:Mol Cell
Main Authors: de Oliveira, Francisco Meirelles Bastos, Kim, Dongsung, Cussiol, Jose Renato, Das, Jishnu, Jeong, Min Cheol, Doerfler, Lillian, Schmidt, Kristina Hildegard, Yu, Haiyuan, Smolka, Marcus Bustamante
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369404/
https://ncbi.nlm.nih.gov/pubmed/25752575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.043
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