A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice

BACKGROUND: Numerous currently incurable human diseases have been causally linked to mutations in connexin (Cx) genes. In several instances, pathological mutations generate abnormally active Cx hemichannels, referred to also as “leaky” hemichannels. The goal of this study was to assay the in vivo ef...

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Publicado en:EBioMedicine
Autores principales: Kuang, Yuanyuan, Zorzi, Veronica, Buratto, Damiano, Ziraldo, Gaia, Mazzarda, Flavia, Peres, Chiara, Nardin, Chiara, Salvatore, Anna Maria, Chiani, Francesco, Scavizzi, Ferdinando, Raspa, Marcello, Qiang, Min, Chu, Youjun, Shi, Xiaojie, Li, Yu, Liu, Lili, Shi, Yaru, Zonta, Francesco, Yang, Guang, Lerner, Richard A., Mammano, Fabio
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378960/
https://ncbi.nlm.nih.gov/pubmed/32553574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102825
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