A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice

BACKGROUND: Numerous currently incurable human diseases have been causally linked to mutations in connexin (Cx) genes. In several instances, pathological mutations generate abnormally active Cx hemichannels, referred to also as “leaky” hemichannels. The goal of this study was to assay the in vivo ef...

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Vydáno v:EBioMedicine
Hlavní autoři: Kuang, Yuanyuan, Zorzi, Veronica, Buratto, Damiano, Ziraldo, Gaia, Mazzarda, Flavia, Peres, Chiara, Nardin, Chiara, Salvatore, Anna Maria, Chiani, Francesco, Scavizzi, Ferdinando, Raspa, Marcello, Qiang, Min, Chu, Youjun, Shi, Xiaojie, Li, Yu, Liu, Lili, Shi, Yaru, Zonta, Francesco, Yang, Guang, Lerner, Richard A., Mammano, Fabio
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
Témata:
Research paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378960/
https://ncbi.nlm.nih.gov/pubmed/32553574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102825
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