A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function

Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations impart a “leaky” character to the affected he...

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Veröffentlicht in:Front Physiol
Hauptverfasser: Ziraldo, Gaia, Buratto, Damiano, Kuang, Yuanyuan, Xu, Liang, Carrer, Andrea, Nardin, Chiara, Chiani, Francesco, Salvatore, Anna Maria, Paludetti, Gaetano, Lerner, Richard A., Yang, Guang, Zonta, Francesco, Mammano, Fabio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6584803/
https://ncbi.nlm.nih.gov/pubmed/31263420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00392
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