Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders

Background: Mutations leading to changes in properties, regulation, or expression of connexin-made channels have been implicated in 28 distinct human hereditary diseases. Eight of these result from variants of connexin 26 (Cx26), a protein critically involved in cell-cell signaling in the inner ear...

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Udgivet i:Front Mol Neurosci
Main Authors: Xu, Liang, Carrer, Andrea, Zonta, Francesco, Qu, Zhihu, Ma, Peixiang, Li, Sheng, Ceriani, Federico, Buratto, Damiano, Crispino, Giulia, Zorzi, Veronica, Ziraldo, Gaia, Bruno, Francesca, Nardin, Chiara, Peres, Chiara, Mazzarda, Flavia, Salvatore, Anna M., Raspa, Marcello, Scavizzi, Ferdinando, Chu, Youjun, Xie, Sichun, Yang, Xuemei, Liao, Jun, Liu, Xiao, Wang, Wei, Wang, Shanshan, Yang, Guang, Lerner, Richard A., Mammano, Fabio
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5615210/
https://ncbi.nlm.nih.gov/pubmed/29018324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00298
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