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Molecular dynamics simulations highlight structural and functional alterations in deafness–related M34T mutation of connexin 26
Mutations of the GJB2 gene encoding the connexin 26 (Cx26) gap junction protein, which is widely expressed in the inner ear, are the primary cause of hereditary non-syndromic hearing loss in several populations. The deafness–associated single amino acid substitution of methionine 34 (M34) in the fir...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3941013/ https://ncbi.nlm.nih.gov/pubmed/24624091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00085 |
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