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Permeation Pathway of Homomeric Connexin 26 and Connexin 30 Channels Investigated by Molecular Dynamics

Mutations in the genes GJB2 and GJB6 encoding human connnexin26 (hCx26) and connexin30 (hCx30), respectively, are the leading cause of non-syndromic prelingual deafness in several human populations. In this work, we exploited the high degree (77%) of sequence similarity shared by hCx26 and hCx30 to...

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Detalhes bibliográficos
Main Authors: Zonta, Francesco, Polles, Guido, Zanotti, Giuseppe, Mammano, Fabio
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500697/
https://ncbi.nlm.nih.gov/pubmed/22292956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/073911012010525027
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