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Permeation Pathway of Homomeric Connexin 26 and Connexin 30 Channels Investigated by Molecular Dynamics

Mutations in the genes GJB2 and GJB6 encoding human connnexin26 (hCx26) and connexin30 (hCx30), respectively, are the leading cause of non-syndromic prelingual deafness in several human populations. In this work, we exploited the high degree (77%) of sequence similarity shared by hCx26 and hCx30 to...

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Détails bibliographiques
Auteurs principaux: Zonta, Francesco, Polles, Guido, Zanotti, Giuseppe, Mammano, Fabio
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500697/
https://ncbi.nlm.nih.gov/pubmed/22292956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/073911012010525027
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