A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice

BACKGROUND: Numerous currently incurable human diseases have been causally linked to mutations in connexin (Cx) genes. In several instances, pathological mutations generate abnormally active Cx hemichannels, referred to also as “leaky” hemichannels. The goal of this study was to assay the in vivo ef...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Kuang, Yuanyuan, Zorzi, Veronica, Buratto, Damiano, Ziraldo, Gaia, Mazzarda, Flavia, Peres, Chiara, Nardin, Chiara, Salvatore, Anna Maria, Chiani, Francesco, Scavizzi, Ferdinando, Raspa, Marcello, Qiang, Min, Chu, Youjun, Shi, Xiaojie, Li, Yu, Liu, Lili, Shi, Yaru, Zonta, Francesco, Yang, Guang, Lerner, Richard A., Mammano, Fabio
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378960/
https://ncbi.nlm.nih.gov/pubmed/32553574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102825
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