A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice

BACKGROUND: Numerous currently incurable human diseases have been causally linked to mutations in connexin (Cx) genes. In several instances, pathological mutations generate abnormally active Cx hemichannels, referred to also as “leaky” hemichannels. The goal of this study was to assay the in vivo ef...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EBioMedicine
Prif Awduron: Kuang, Yuanyuan, Zorzi, Veronica, Buratto, Damiano, Ziraldo, Gaia, Mazzarda, Flavia, Peres, Chiara, Nardin, Chiara, Salvatore, Anna Maria, Chiani, Francesco, Scavizzi, Ferdinando, Raspa, Marcello, Qiang, Min, Chu, Youjun, Shi, Xiaojie, Li, Yu, Liu, Lili, Shi, Yaru, Zonta, Francesco, Yang, Guang, Lerner, Richard A., Mammano, Fabio
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2020
Pynciau:
Research paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378960/
https://ncbi.nlm.nih.gov/pubmed/32553574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102825
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