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A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice
BACKGROUND: Numerous currently incurable human diseases have been causally linked to mutations in connexin (Cx) genes. In several instances, pathological mutations generate abnormally active Cx hemichannels, referred to also as “leaky” hemichannels. The goal of this study was to assay the in vivo ef...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | EBioMedicine |
|---|---|
| Prif Awduron: | , , , , , , , , , , , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Elsevier
2020
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7378960/ https://ncbi.nlm.nih.gov/pubmed/32553574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102825 |
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