AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells

Steroid hormones, including glucocorticoids and androgens, have potent actions to regulate many cellular processes within the liver. The steroid A-ring reductase, 5β-reductase (AKR1D1), is predominantly expressed in the liver, where it inactivates steroid hormones and, in addition, plays a crucial r...

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Udgivet i:J Steroid Biochem Mol Biol
Main Authors: Nikolaou, Nikolaos, Gathercole, Laura L., Kirkwood, Lucy, Dunford, James E., Hughes, Beverly A., Gilligan, Lorna C., Oppermann, Udo, Penning, Trevor M., Arlt, Wiebke, Hodson, Leanne, Tomlinson, Jeremy W.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375835/
https://ncbi.nlm.nih.gov/pubmed/30769091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2019.02.002
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