AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells

Steroid hormones, including glucocorticoids and androgens, have potent actions to regulate many cellular processes within the liver. The steroid A-ring reductase, 5β-reductase (AKR1D1), is predominantly expressed in the liver, where it inactivates steroid hormones and, in addition, plays a crucial r...

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Publicado en:J Steroid Biochem Mol Biol
Autores principales: Nikolaou, Nikolaos, Gathercole, Laura L., Kirkwood, Lucy, Dunford, James E., Hughes, Beverly A., Gilligan, Lorna C., Oppermann, Udo, Penning, Trevor M., Arlt, Wiebke, Hodson, Leanne, Tomlinson, Jeremy W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375835/
https://ncbi.nlm.nih.gov/pubmed/30769091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2019.02.002
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