Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo

Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates endogenous glucocorticoids and catalyses an important step in bile acid synthesis. Endogenous and synthetic glucocorticoids are potent regulators of metabolic phenotype and play a crucial role in hepatic glucose me...

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Bibliografische gegevens
Gepubliceerd in:J Endocrinol
Hoofdauteurs: Nikolaou, Nikolaos, Arvaniti, Anastasia, Appanna, Nathan, Sharp, Anna, Hughes, Beverly A, Digweed, Dena, Whitaker, Martin J, Ross, Richard, Arlt, Wiebke, Penning, Trevor M, Morris, Karen, George, Sherly, Keevil, Brian G, Hodson, Leanne, Gathercole, Laura L, Tomlinson, Jeremy W
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Bioscientifica Ltd 2020
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7182088/
https://ncbi.nlm.nih.gov/pubmed/32106090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-19-0473
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