Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo

Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates endogenous glucocorticoids and catalyses an important step in bile acid synthesis. Endogenous and synthetic glucocorticoids are potent regulators of metabolic phenotype and play a crucial role in hepatic glucose me...

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Detalhes bibliográficos
Publicado no:J Endocrinol
Main Authors: Nikolaou, Nikolaos, Arvaniti, Anastasia, Appanna, Nathan, Sharp, Anna, Hughes, Beverly A, Digweed, Dena, Whitaker, Martin J, Ross, Richard, Arlt, Wiebke, Penning, Trevor M, Morris, Karen, George, Sherly, Keevil, Brian G, Hodson, Leanne, Gathercole, Laura L, Tomlinson, Jeremy W
Formato: Artigo
Idioma:Inglês
Publicado em: Bioscientifica Ltd 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7182088/
https://ncbi.nlm.nih.gov/pubmed/32106090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-19-0473
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