Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation

RNA helicase DDX21 plays vital roles in ribosomal RNA biogenesis, transcription, and the regulation of host innate immunity during virus infection. How DDX21 recognizes and unwinds RNA and how DDX21 interacts with virus remain poorly understood. Here, crystal structures of human DDX21 determined in...

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Bibliographic Details
Published in:Adv Sci (Weinh)
Main Authors: Chen, Zijun, Li, Zhengyang, Hu, Xiaojian, Xie, Feiyan, Kuang, Siyun, Zhan, Bowen, Gao, Wenqing, Chen, Xiangjun, Gao, Siqi, Li, Yang, Wang, Yongming, Qian, Feng, Ding, Chen, Gan, Jianhua, Ji, Chaoneng, Xu, Xue‐Wei, Zhou, Zheng, Huang, Jinqing, He, Housheng Hansen, Li, Jixi
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375243/
https://ncbi.nlm.nih.gov/pubmed/32714761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202000532
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