Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation

RNA helicase DDX21 plays vital roles in ribosomal RNA biogenesis, transcription, and the regulation of host innate immunity during virus infection. How DDX21 recognizes and unwinds RNA and how DDX21 interacts with virus remain poorly understood. Here, crystal structures of human DDX21 determined in...

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Detalhes bibliográficos
Publicado no:Adv Sci (Weinh)
Main Authors: Chen, Zijun, Li, Zhengyang, Hu, Xiaojian, Xie, Feiyan, Kuang, Siyun, Zhan, Bowen, Gao, Wenqing, Chen, Xiangjun, Gao, Siqi, Li, Yang, Wang, Yongming, Qian, Feng, Ding, Chen, Gan, Jianhua, Ji, Chaoneng, Xu, Xue‐Wei, Zhou, Zheng, Huang, Jinqing, He, Housheng Hansen, Li, Jixi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375243/
https://ncbi.nlm.nih.gov/pubmed/32714761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202000532
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