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The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X

DEAD-box helicases (DDXs) regulate RNA processing and metabolism by unwinding short double-stranded (ds) RNAs. Sharing a helicase core composed of two RecA-like domains (D1D2), DDXs function in an ATP-dependent, non-processive manner. As an attractive target for cancer and AIDS treatment, DDX3X and...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Song, He, Ji, Xinhua
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6626043/
https://ncbi.nlm.nih.gov/pubmed/31300642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11083-2
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