Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation

RNA helicase DDX21 plays vital roles in ribosomal RNA biogenesis, transcription, and the regulation of host innate immunity during virus infection. How DDX21 recognizes and unwinds RNA and how DDX21 interacts with virus remain poorly understood. Here, crystal structures of human DDX21 determined in...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Adv Sci (Weinh)
Main Authors: Chen, Zijun, Li, Zhengyang, Hu, Xiaojian, Xie, Feiyan, Kuang, Siyun, Zhan, Bowen, Gao, Wenqing, Chen, Xiangjun, Gao, Siqi, Li, Yang, Wang, Yongming, Qian, Feng, Ding, Chen, Gan, Jianhua, Ji, Chaoneng, Xu, Xue‐Wei, Zhou, Zheng, Huang, Jinqing, He, Housheng Hansen, Li, Jixi
פורמט: Artigo
שפה:Inglês
יצא לאור: John Wiley and Sons Inc. 2020
נושאים:
Full Papers
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375243/
https://ncbi.nlm.nih.gov/pubmed/32714761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202000532
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