SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

We show that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain. Docking studies suggest a putative heparin/heparan sulfate-binding site adjacent to the domain that binds to ACE2. In vitro, binding of AC...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :bioRxiv
Главные авторы: Clausen, Thomas Mandel, Sandoval, Daniel R., Spliid, Charlotte B., Pihl, Jessica, Painter, Chelsea D., Thacker, Bryan E., Glass, Charles A., Narayanan, Anoop, Majowicz, Sydney A., Zhang, Yang, Torres, Jonathan L., Golden, Gregory J., Porell, Ryan, Garretson, Aaron F., Laubach, Logan, Feldman, Jared, Yin, Xin, Pu, Yuan, Hauser, Blake, Caradonna, Timothy M., Kellman, Benjamin P., Martino, Cameron, Gordts, Philip L.S.M., Leibel, Sandra L., Chanda, Summit K., Schmidt, Aaron G., Godula, Kamil, Jose, Joyce, Corbett, Kevin D., Ward, Andrew B., Carlin, Aaron F., Esko, Jeffrey D.
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory 2020
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373134/
https://ncbi.nlm.nih.gov/pubmed/32699853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.14.201616
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы