SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

We show that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain. Docking studies suggest a putative heparin/heparan sulfate-binding site adjacent to the domain that binds to ACE2. In vitro, binding of AC...

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Publicado no:bioRxiv
Main Authors: Clausen, Thomas Mandel, Sandoval, Daniel R., Spliid, Charlotte B., Pihl, Jessica, Painter, Chelsea D., Thacker, Bryan E., Glass, Charles A., Narayanan, Anoop, Majowicz, Sydney A., Zhang, Yang, Torres, Jonathan L., Golden, Gregory J., Porell, Ryan, Garretson, Aaron F., Laubach, Logan, Feldman, Jared, Yin, Xin, Pu, Yuan, Hauser, Blake, Caradonna, Timothy M., Kellman, Benjamin P., Martino, Cameron, Gordts, Philip L.S.M., Leibel, Sandra L., Chanda, Summit K., Schmidt, Aaron G., Godula, Kamil, Jose, Joyce, Corbett, Kevin D., Ward, Andrew B., Carlin, Aaron F., Esko, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373134/
https://ncbi.nlm.nih.gov/pubmed/32699853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.14.201616
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