SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

We show that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain. Docking studies suggest a putative heparin/heparan sulfate-binding site adjacent to the domain that binds to ACE2. In vitro, binding of AC...

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Published in:bioRxiv
Main Authors: Clausen, Thomas Mandel, Sandoval, Daniel R., Spliid, Charlotte B., Pihl, Jessica, Painter, Chelsea D., Thacker, Bryan E., Glass, Charles A., Narayanan, Anoop, Majowicz, Sydney A., Zhang, Yang, Torres, Jonathan L., Golden, Gregory J., Porell, Ryan, Garretson, Aaron F., Laubach, Logan, Feldman, Jared, Yin, Xin, Pu, Yuan, Hauser, Blake, Caradonna, Timothy M., Kellman, Benjamin P., Martino, Cameron, Gordts, Philip L.S.M., Leibel, Sandra L., Chanda, Summit K., Schmidt, Aaron G., Godula, Kamil, Jose, Joyce, Corbett, Kevin D., Ward, Andrew B., Carlin, Aaron F., Esko, Jeffrey D.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373134/
https://ncbi.nlm.nih.gov/pubmed/32699853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.14.201616
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