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Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions
Surfen, bis-2-methyl-4-amino-quinolyl-6-carbamide, was previously reported as a small molecule antagonist of heparan sulfate (HS), a key cell-surface glycosaminoglycan found on all mammalian cells. To generate structure–activity relationships, a series of rationally designed surfen analogs was synth...
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| Pubblicato in: | Chem Sci |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5267326/ https://ncbi.nlm.nih.gov/pubmed/28133533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01208b |
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