Surfen, a small molecule antagonist of heparan sulfate

In a search for small molecule antagonists of heparan sulfate, we examined the activity of bis-2-methyl-4-amino-quinolyl-6-carbamide, also known as surfen. Fluorescence-based titrations indicated that surfen bound to glycosaminoglycans, and the extent of binding increased according to charge density...

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Bibliografiske detaljer
Main Authors: Schuksz, Manuela, Fuster, Mark M., Brown, Jillian R., Crawford, Brett E., Ditto, David P., Lawrence, Roger, Glass, Charles A., Wang, Lianchun, Tor, Yitzhak, Esko, Jeffrey D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529023/
https://ncbi.nlm.nih.gov/pubmed/18725627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805862105
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