Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis

To examine the role of endothelial heparan sulfate during angiogenesis, we generated mice bearing an endothelial-targeted deletion in the biosynthetic enzyme N-acetylglucosamine N-deacetylase/N-sulfotransferase 1 (Ndst1). Physiological angiogenesis during cutaneous wound repair was unaffected, as wa...

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Detalhes bibliográficos
Main Authors: Fuster, Mark M., Wang, Lianchun, Castagnola, Janice, Sikora, Lyudmila, Reddi, Krisanavane, Lee, Phillip H.A., Radek, Katherine A., Schuksz, Manuela, Bishop, Joseph R., Gallo, Richard L., Sriramarao, P., Esko, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064806/
https://ncbi.nlm.nih.gov/pubmed/17470635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200610086
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