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Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate

Heparan sulfate (HS) proteoglycans bind extracellular proteins that participate in cell signaling, attachment, and endocytosis. These interactions depend on the arrangement of sulfated sugars in the HS chains generated by well-characterized biosynthetic enzymes; however the regulation of these enzym...

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Dades bibliogràfiques
Publicat a:Nat Chem Biol
Autors principals: Weiss, Ryan J., Spahn, Philipp N., Chiang, Austin W.T., Liu, Qing, Li, Jing, Hamill, Kristina M., Rother, Sandra, Clausen, Thomas M., Hoeksema, Marten A., Timm, Bryce M., Godula, Kamil, Glass, Christopher K., Tor, Yitzhak, Gordts, Philip L.S.M., Lewis, Nathan E., Esko, Jeffrey D.
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159865/
https://ncbi.nlm.nih.gov/pubmed/33846619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-021-00776-9
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