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Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate

Heparan sulfate (HS) proteoglycans bind extracellular proteins that participate in cell signaling, attachment, and endocytosis. These interactions depend on the arrangement of sulfated sugars in the HS chains generated by well-characterized biosynthetic enzymes; however the regulation of these enzym...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Weiss, Ryan J., Spahn, Philipp N., Chiang, Austin W.T., Liu, Qing, Li, Jing, Hamill, Kristina M., Rother, Sandra, Clausen, Thomas M., Hoeksema, Marten A., Timm, Bryce M., Godula, Kamil, Glass, Christopher K., Tor, Yitzhak, Gordts, Philip L.S.M., Lewis, Nathan E., Esko, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159865/
https://ncbi.nlm.nih.gov/pubmed/33846619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-021-00776-9
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