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Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate

Heparan sulfate (HS) proteoglycans bind extracellular proteins that participate in cell signaling, attachment, and endocytosis. These interactions depend on the arrangement of sulfated sugars in the HS chains generated by well-characterized biosynthetic enzymes; however the regulation of these enzym...

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書目詳細資料
發表在:Nat Chem Biol
Main Authors: Weiss, Ryan J., Spahn, Philipp N., Chiang, Austin W.T., Liu, Qing, Li, Jing, Hamill, Kristina M., Rother, Sandra, Clausen, Thomas M., Hoeksema, Marten A., Timm, Bryce M., Godula, Kamil, Glass, Christopher K., Tor, Yitzhak, Gordts, Philip L.S.M., Lewis, Nathan E., Esko, Jeffrey D.
格式: Artigo
語言:Inglês
出版: 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159865/
https://ncbi.nlm.nih.gov/pubmed/33846619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-021-00776-9
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