Clonal evolution driven by superdriver mutations

BACKGROUND: Tumors are widely recognized to progress through clonal evolution by sequentially acquiring selectively advantageous genetic alterations that significantly contribute to tumorigenesis and thus are termned drivers. Some cancer drivers, such as TP53 point mutation or EGFR copy number gain,...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Evol Biol
Main Authors: Grossmann, Patrick, Cristea, Simona, Beerenwinkel, Niko
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Methodology Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7370525/
https://ncbi.nlm.nih.gov/pubmed/32689942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12862-020-01647-y
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