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Clonal evolution driven by superdriver mutations

BACKGROUND: Tumors are widely recognized to progress through clonal evolution by sequentially acquiring selectively advantageous genetic alterations that significantly contribute to tumorigenesis and thus are termned drivers. Some cancer drivers, such as TP53 point mutation or EGFR copy number gain,...

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Detalhes bibliográficos
Publicado no:BMC Evol Biol
Main Authors: Grossmann, Patrick, Cristea, Simona, Beerenwinkel, Niko
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7370525/
https://ncbi.nlm.nih.gov/pubmed/32689942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12862-020-01647-y
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