Single cell mutation analysis of clonal evolution in myeloid malignancies

Myeloid malignancies, including acute myeloid leukemia (AML), arise from the expansion of hematopoietic stem/progenitor cells which acquire somatic mutations. Bulk molecular profiling suggests step-wise mutation acquisition, where mutant genes with high variant allele frequencies (VAFs) occur early...

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Publicado en:Nature
Autores principales: Miles, Linde A., Bowman, Robert L., Merlinsky, Tiffany R., Csete, Isabelle S., Ooi, Aik T., Durruthy-Durruthy, Robert, Bowman, Michael, Famulare, Christopher, Patel, Minal A., Mendez, Pedro, Ainali, Chrysanthi, Demaree, Benjamin, Delley, Cyrille L., Abate, Adam R., Manivannan, Manimozhi, Sahu, Sombeet, Goldberg, Aaron D., Bolton, Kelly L., Zehir, Ahmet, Rampal, Raajit, Carroll, Martin P., Meyer, Sara E., Viny, Aaron D., Levine, Ross L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677169/
https://ncbi.nlm.nih.gov/pubmed/33116311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2864-x
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