Single cell mutation analysis of clonal evolution in myeloid malignancies

Myeloid malignancies, including acute myeloid leukemia (AML), arise from the expansion of hematopoietic stem/progenitor cells which acquire somatic mutations. Bulk molecular profiling suggests step-wise mutation acquisition, where mutant genes with high variant allele frequencies (VAFs) occur early...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Nature
Auteurs principaux: Miles, Linde A., Bowman, Robert L., Merlinsky, Tiffany R., Csete, Isabelle S., Ooi, Aik T., Durruthy-Durruthy, Robert, Bowman, Michael, Famulare, Christopher, Patel, Minal A., Mendez, Pedro, Ainali, Chrysanthi, Demaree, Benjamin, Delley, Cyrille L., Abate, Adam R., Manivannan, Manimozhi, Sahu, Sombeet, Goldberg, Aaron D., Bolton, Kelly L., Zehir, Ahmet, Rampal, Raajit, Carroll, Martin P., Meyer, Sara E., Viny, Aaron D., Levine, Ross L.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677169/
https://ncbi.nlm.nih.gov/pubmed/33116311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2864-x
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires