Dynamic human MutSα–MutLα complexes compact mismatched DNA

DNA mismatch repair (MMR) corrects errors that occur during DNA replication. In humans, mutations in the proteins MutSα and MutLα that initiate MMR cause Lynch syndrome, the most common hereditary cancer. MutSα surveilles the DNA, and upon recognition of a replication error it undergoes adenosine tr...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Bradford, Kira C., Wilkins, Hunter, Hao, Pengyu, Li, Zimeng M., Wang, Bangchen, Burke, Dan, Wu, Dong, Smith, Austin E., Spaller, Logan, Du, Chunwei, Gauer, Jacob W., Chan, Edward, Hsieh, Peggy, Weninger, Keith R., Erie, Dorothy A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368325/
https://ncbi.nlm.nih.gov/pubmed/32586954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1918519117
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